Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases. Issue 8 (27th December 2018)

• Record Type: Journal Article
• Authors: Zhu, Yueqi; Zhang, Hongbo; Zhang, Yiran; Wu, Huayin; Wei, Liming; Zhou, Gen; Zhang, Yuezhou; Deng, Lianfu; Cheng, Yingsheng; Li, Minghua; Santos, Hélder A.; Cui, Wenguo
• Is Part Of: Advanced materials. Volume 31:Issue 8(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-27
• Subjects: biodegradable -- cerebrovascular disease -- drug elution -- flexible endovascular devices -- metal‐based stents; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201805452
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Nowadays, platinum coils with or without biological modification have become routine embolization devices to reduce the risk of cerebral aneurysm bleeding. Additionally, many intracranial stents, flow diverters, and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an in‐depth understanding of the mechanical and material performance of these metal‐based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, the pros and cons of the current structural designs are discussed when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety, and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed. Abstract : An overview of the advantages and disadvantages of metal devices used in the treatment of cerebrovascular diseases is provided; for example, embolic devices (coils), stents, flow diverting devices, and stent retrievers. Promising new developments in biodegradable metal materials and drug elution techniques for further clinical applications are also discussed.