Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions. Issue 8 (5th February 2019)

• Record Type: Journal Article
• Authors: Guo, Jia; Xu, Cong; Liu, Xiaowei; Wang, Mang
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 8(2019)
• Page Start: 2162
• Page End: 2168
• Publication Date: 2019-02-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob03189d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. Abstract : A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3 Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.