A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans. Issue 8 (31st January 2019)

• Record Type: Journal Article
• Authors: Sivaraman, Aneesh; Harmalkar, Dipesh S.; Kang, Jiyoon; Choi, Yongseok; Lee, Kyeong
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 8(2019)
• Page Start: 2153
• Page End: 2161
• Publication Date: 2019-01-31
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob03102a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : One-pot synthesis of 2-bromo-6-hydroxybenzofurans and their applications in the divergent synthesis of bioactive benzofurans are successfully established. Abstract : 2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.