A tandem dearomatization/rearomatization strategy: enantioselective N-heterocyclic carbene-catalyzed α-arylation. Issue 8 (15th January 2019)
- Record Type:
- Journal Article
- Title:
- A tandem dearomatization/rearomatization strategy: enantioselective N-heterocyclic carbene-catalyzed α-arylation. Issue 8 (15th January 2019)
- Main Title:
- A tandem dearomatization/rearomatization strategy: enantioselective N-heterocyclic carbene-catalyzed α-arylation
- Authors:
- Wu, Zijun
Wang, Jian - Abstract:
- Abstract : In this study, the first example of carbene-catalyzed tandem dearomatization/rearomatization reaction of azonaphthalenes with α-chloroaldehydes is described. Abstract : In this study, the first example of the carbene-catalyzed tandem dearomatization/rearomatization reaction of azonaphthalenes with α-chloroaldehydes is described. This protocol enables the efficient assembly of chiral dihydrocinnolinone derivatives in good yields with excellent enantioselectivities (up to 99% ee). Moreover, this strategy enables not only the highly enantioselective NHC-catalyzed nucleophilic aromatic substitution, but also a formal Csp 2 –Csp 3 bond formation.
- Is Part Of:
- Chemical science. Volume 10:Issue 8(2019)
- Journal:
- Chemical science
- Issue:
- Volume 10:Issue 8(2019)
- Issue Display:
- Volume 10, Issue 8 (2019)
- Year:
- 2019
- Volume:
- 10
- Issue:
- 8
- Issue Sort Value:
- 2019-0010-0008-0000
- Page Start:
- 2501
- Page End:
- 2506
- Publication Date:
- 2019-01-15
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/SC ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8sc04601h ↗
- Languages:
- English
- ISSNs:
- 2041-6520
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3151.490000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 9555.xml