Association between postprandial hyperglycemia at clinic visits and all-cause and cancer mortality in patients with type 2 diabetes: A long-term historical cohort study in Japan. (February 2019)

• Record Type: Journal Article
• Authors: Takao, Toshiko; Takahashi, Kazuyuki; Suka, Machi; Suzuki, Nobumi; Yanagisawa, Hiroyuki
• Is Part Of: Diabetes research and clinical practice. Volume 148(2019)
• Page Start: 152
• Page End: 159
• Publication Date: 2019-02
• Subjects: All-cause mortality -- Cancer mortality -- Clinic visit -- Postprandial hyperglycemia -- Type 2 diabetes; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2019.01.006
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Postprandial hyperglycemia may be associated with all-cause and cancer mortality. This association can be independent of HbA1c levels in a real-world setting. The average age at death was 75.6 years in men and 80.8 years in women. Age at death in type 2 diabetes patients might be approaching that in other people. Abstract: Aims: To evaluate the effect of postprandial hyperglycemia at clinic visits on all-cause and cancer mortality independent of glycated hemoglobin (HbA1c) levels in a real-world setting in Japanese patients with type 2 diabetes. We also investigated age at death. Methods: This historical cohort study included 1582 patients with type 2 diabetes who first visited our clinic from 1995 to 1998 and continued visiting for at least 1 year. The patients were followed up through 2017. Blood glucose levels at 2 h ± 30 min post-breakfast (2h-PBBG) were measured in 926 patients during the first year. The first measurements of 2h-PBBG levels were used as a measure of postprandial hyperglycemia. Results: A total of 233 patients died. The average age at death (men/women) was 75.6/80.8 years. A total of 139 patients who had 2h-PBBG levels measured died, including 46 deaths from cancer. Multivariate Cox regression analysis showed that 2h-PBBG levels significantly predicted all-cause and cancer mortality independent of HbA1c levels. Conclusions: Postprandial hyperglycemia at clinic visits may be associated with all-cause and cancer mortality in patients with type 2 diabetes independent of HbA1c levels. As this is a small observational study, further studies are warranted to confirm our findings.