Slow, slurred speech as an initial complaint in amyotrophic lateral sclerosis. Issue 2 (April 2019)

• Record Type: Journal Article
• Authors: Tsunoda, Koichi; Takazawa, Mihiro; Chong, Tonghyo; Morita, Yoko
• Is Part Of: Auris nasus larynx. Volume 46:Issue 2(2019)
• Page Start: 193
• Page End: 195
• Publication Date: 2019-04
• Subjects: Slow speech -- Slurred speech -- Diagnostic indicator -- Amyotrophic lateral sclerosis; Otolaryngology -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.anl.2018.07.007
• Languages: English
• ISSNs: 0385-8146

Abstract

Abstracts: Objective: Otorhinolaryngologic examinations at an early stage, particularly those conducted by vocal specialists, can make potentially important contributions to the diagnosis of bulbar-onset ALS patients. Methods: We analyzed 2623 patients (2010–2017) visited the ENT Voice Clinic, National Hospital Organization Tokyo Medical Center, with the primary complaint of speech or vocal dysfunction at the initial visit. Among those, 12 patients visited the voice clinic after consultations with other physicians but before receiving a diagnosis and we initially suspected bulbar-onset ALS due to slow, slurred speech (SSS). We analyzed the detail of those suspected ALS cases. Results: Every patient suspected ALS patients consulted an average of 2.2 physicians before visiting the voice clinic and a total of 3.2 physicians before receiving the final diagnosis. The mean speech symptom duration before visiting the vocal clinic was 7.83 months in ALS, 24 months in MSA patients. The duration until final diagnosis after we referred them to neurologists was 2.16 months and 15.3 months, respectively. Conclusion: Otolaryngologists and primary care physicians to consider the possibility of ALS when patients present even with an only symptom of SSS. They should then refer such patients to neurologists for definitive diagnoses, leading to early detection and treatment of ALS.