Epidemiology study of pediatric primary intussusception aged ≤24 months in pre-rotavirus vaccine era of Jinan, China. Issue 11 (7th March 2019)

• Record Type: Journal Article
• Authors: Zhang, Tiantian; Cui, Liangliang; Geng, Xingyi; Yu, Xiaolin; Zhang, Ji
• Is Part Of: Vaccine. Volume 37:Issue 11(2019)
• Page Start: 1436
• Page End: 1442
• Publication Date: 2019-03-07
• Subjects: Pediatric intussusception -- Rotavirus vaccination -- Epidemiology; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2019.01.060
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: Introduction: Few studies have reported on the epidemiological characteristics of pediatric primary intussusception in the pre-rotavirus vaccine era of China. It is important to complementary baseline data before rotavirus vaccine introduction in China. This study conduct a retrospective investigation and evaluated the incidence rate, described the epidemiology of pediatric primary intussusception aged ≤24 months. Methods: We conducted a retrospective investigation in all secondary- and tertiary-hospitals in Jinan. Pediatric primary intussusception inpatients aged ≤24 months were identified depending on ICD-10 discharge code from a total of 63 hospitals from 2011 to 2015. Demographic and clinical information were extracting from the electronic clinical record systems. Results: A total of 575 pediatric primary intussusception inpatients were identified with average annual incidence of 86.5 per 100, 000. A significantly higher incidence was observed in males (χ2 = 13.8, P < 0.01), in the ≤12 months old age group (χ2 = 19.5, P < 0.01) and from the urban areas (χ2 = 63.31, P < 0.001). No clear seasonality found. Abdominal pain (80.9%) and vomiting (63.3%) were the most frequently reported. Most intussusception cases occurred in ileo-cecum. Over 92% of intussusception cases were diagnosed by ultrasound alone and 77.4% was successfully treated by air enema. 99.7% were cured. The median time of hospitalization was 2 days (range: 0–35 days). Conclusion: This retrospective study provides baseline information of incidence, epidemiologyand clinical characteristics of pediatric primary intussusception in Jinan City during 2011–2016 before the introduction of rotavirus vaccine. It will be important for evaluating safety of rotavirus vaccine if it will be introduced to the routine immunization program in China.