Adipose tissue dendritic cells in steady‐state. Issue 3 (13th January 2019)

• Record Type: Journal Article
• Authors: Macdougall, Claire E.; Longhi, M. Paula
• Is Part Of: Immunology. Volume 156:Issue 3(2019)
• Page Start: 228
• Page End: 234
• Publication Date: 2019-01-13
• Subjects: adipose tissue -- dendritic cells -- steady‐state -- tissue metabolism; Immunology -- Periodicals
• DOI: 10.1111/imm.13034
• Languages: English
• ISSNs: 0019-2805

Abstract

Summary: Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whereas dysfunctional WAT plays a prominent role in the development of obesity‐associated co‐morbidities. Tissue‐resident immune cells are important for maintaining WAT homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. Due to phenotypic overlap with other myeloid cells, the distinct contribution of WAT cDCs has been poorly understood. This review will discuss the contribution of cDCs in the maintenance of WAT homeostasis. In particular, the review will focus on the metabolic cross‐talk between cDCs and adipocytes that regulates local immune responses during physiological conditions. Abstract : Tissue resident immune cells are important for maintaining white adipose tissue (WAT) homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. We discuss the contribution of cDCs in the maintenance of WAT homeostasis and focus on the metabolic cross‐talk between cDCs and adipocytes that regulates local immune responses during physiological conditions.