Perfluorocarbon-based O2 nanocarrier for efficient photodynamic therapy. Issue 7 (28th January 2019)

• Record Type: Journal Article
• Authors: Hu, Huamin; Yan, Xuefeng; Wang, Hui; Tanaka, Joji; Wang, Mengzhe; You, Wei; Li, Zibo
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 7(2019)
• Page Start: 1116
• Page End: 1123
• Publication Date: 2019-01-28
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb01844h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A series of polymer micelles with a perfluorocarbon (PFC) core to carry both PS and O2 to tumor sites was prepared. These new PFC formulation not only improved the production of 1 O2 and enhanced the PDT efficiency, but also significantly reduced cell toxicity compared with the one without a perfluoro unit. Abstract : Tumor hypoxia is considered as one of the major factors that limit the efficiency of photodynamic therapy (PDT), in which oxygen (O2 ) is needed to generate singlet oxygen ( 1 O2 ) for cell destruction. Inspired by the excellent O2 carrying ability of perfluorocarbon molecules in artificial blood, we prepared a series of polymer micelles with a perfluorocarbon core to carry both photo-sensitizer and O2 to the tumor site, aiming to improve PDT efficiency. We found that the accelerated generation of 1 O2 correlated with the increased perfluorocarbon amount in solution. In vitro cell study further showed that the new perfluorocarbon formulation not only improved the production of 1 O2, leading to enhanced photodynamic therapy efficiency, but also significantly reduced cell toxicity when compared with the one without these perfluoro units. This work provides a new option for improving PDT efficiency with the new perfluorocarbon-incorporated nanoplatform.