"Top" or "bottom" switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate. Issue 15 (31st January 2019)

• Record Type: Journal Article
• Authors: Hu, Yujing; Wang, Jie; Cen, Yixin; Zheng, He; Huang, Meilan; Lin, Xianfu; Wu, Qi
• Is Part Of: Chemical communications. Volume 55:Issue 15(2019)
• Page Start: 2198
• Page End: 2201
• Publication Date: 2019-01-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09951k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Single mutation F432I/L or L435A/G remarkably reversed the (−)-selectivity of WT CHMOAcineto . Abstract : Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).