Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds. Issue 4 (8th January 2019) - Fan, Jian
Abstract : A copper-mediated tandem addition/cyclization/carbon–carbon cleavage reaction for the convenient synthesis of 2-acyl trisubstituted furans has been developed. Abstract : A simple and convenient approach for the construction of 2-acetyl trisubstituted furans with acetylenic ketones and 1, 3-dicarbonyl compounds via Cu-mediated unstrained C(sp 3 )–C(sp 2 ) bond cleavage has been described. Mechanistic studies indicate that this transformation proceeds via a sequence of addition, cyclization, and C–C bond cleavage to afford the corresponding products in moderate to good yields.