Benzene construction via Pd-catalyzed cyclization of 2, 7-alkadiynylic carbonates in the presence of alkynes. Issue 7 (4th January 2019)

• Record Type: Journal Article
• Authors: Zhang, Yuchen; Wu, Wangteng; Fu, Chunling; Huang, Xin; Ma, Shengming
• Is Part Of: Chemical science. Volume 10:Issue 7(2019)
• Page Start: 2228
• Page End: 2235
• Publication Date: 2019-01-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8sc04681f
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A palladium-catalyzed highly regio- and chemo-selective cyclization to construct 1, 3-dihydroisobenzofuran and isoindoline derivatives under mild conditions has been developed. Abstract : A palladium-catalyzed highly regio- and chemo-selective cyclization of 2, 7-alkadiynylic carbonates with functionalized alkynes to construct 1, 3-dihydroisobenzofuran and isoindoline derivatives under mild conditions has been developed. Functional groups such as alcohol, sulfonamide, and indoles could be well tolerated. After careful mechanistic studies, a mechanism involving oxidative addition and regioselectivity-defined double alkyne insertions has been proposed.