An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition. Issue 3 (March 2019)

• Record Type: Journal Article
• Authors: Mattson, Mark P.
• Is Part Of: Trends in cognitive sciences. Volume 23:Issue 3(2019)
• Page Start: 200
• Page End: 212
• Publication Date: 2019-03
• Subjects: brain evolution -- epigenetic modifications -- hippocampus -- intermittent fasting -- ketogenic state -- obesity -- prefrontal cortex -- spatial navigation; Cognitive science -- Periodicals; Cognitive neuroscience -- Periodicals; 153.05
• DOI: 10.1016/j.tics.2019.01.003
• Languages: English
• ISSNs: 1364-6613

Abstract

Abstract : Brain structures and neuronal networks that mediate spatial navigation, decision-making, sociality, and creativity evolved, in part, to enable success in food acquisition. Here, I discuss evidence suggesting that the reason that overconsumption of energy-rich foods negatively impacts cognition is that signaling pathways that evolved to respond adaptively to food scarcity are relatively disengaged in the setting of continuous food availability. Obesity impairs cognition and increases the risk for some psychiatric disorders and dementias. Moreover, maternal and paternal obesity predispose offspring to poor cognitive outcomes by epigenetic molecular mechanisms. Neural signaling pathways that evolved to bolster cognition in settings of food insecurity can be stimulated by intermittent fasting and exercise to support the cognitive health of current and future generations. Highlights: Neuronal networks in brain regions critical for spatial navigation and decision-making evolved to enable success in competition for limited food availability in hazardous environments. A major ecological factor that drove the evolution of cognition, namely food scarcity, has been largely eliminated from the day-to-day experiences of modern-day humans and domesticated animals. Continuous availability and consumption of energy-rich food in relatively sedentary modern-day humans negatively impacts the lifetime cognitive trajectories of parents and their children. Epigenetic molecular DNA and chromatin protein modifications are impacted by energy intake and can propagate to future generations. The cellular and molecular mechanisms by which intermittent food deprivation enhances cognition and overfeeding impairs cognition are being elucidated. A better understanding of the food-centric evolutionary foundations of human brain neuroplasticity is leading to the development of novel bioenergetic challenge-based patterns of eating and exercise aimed at improving cognitive health and resilience.