Hypoconnectivity of insular resting-state networks in adolescents with Autism Spectrum Disorder. (30th January 2019)

• Record Type: Journal Article
• Authors: Francis, Sunday M.; Camchong, Jazmin; Brickman, Laura; Goelkel-Garcia, Liliana; Mueller, Bryon A.; Tseng, Angela; Lim, Kelvin O.; Jacob, Suma
• Is Part Of: Psychiatry research. Volume 283(2019)
• Page Start: 104
• Page End: 112
• Publication Date: 2019-01-30
• Subjects: Anterior insula -- Posterior insula -- Autism spectrum disorder -- Neurodevelopment -- Resting-state functional connectivity -- Salience network -- Social communication questionnaire; Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2018.12.003
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Hypoconnectivity was observed in youths with autism during resting-state. Functional connectivity was associated with social scores in the combined group. Age effects were observed in the autism sample. Abstract: Autism Spectrum Disorder (ASD) is characterized by deficits in social interaction and communication. The anterior insula (AI) participates in emotional salience detection; and the posterior insula (PI) participates in sensorimotor integration and response selection. Meta-analyses have noted insula-based aberrant connectivity within ASD. Given the observed social impairments in ASD and the role of the insula in social information processing (SIP), investigating functional organization of this structure in ASD is important. We investigated differences in resting-state functional connectivity (RSFC) using fMRI in male youths with ( N =13; mean=14.6 years; range: 10.2–18.0 years) and without ASD ( N =17; mean=14.5 years; range: 10.0–17.5 years). With seed-based FC measures, we compared RSFC in insular networks. Hypoconnectivity was observed in ASD (AI-superior frontal gyrus (SFG); AI-thalamus; PI-inferior parietal lobule (IPL); PI-fusiform gyrus (FG); PI-lentiform nucleus/putamen). Using the Social Communication Questionnaire (SCQ) to assess social functioning, regression analyses yielded negative correlations between SCQ scores and RSFC (AI-SFG; AI-thalamus; PI-FG; PI-IPL). Given the insula's connections to limbic regions, and its role in integrating external sensory stimuli with internal states, atypical activity in this structure may be associated with social deficits characterizing ASD. Our results suggest further investigation of the insula's role in SIP across a continuum of social abilities is needed.