Salvianolic acid inhibits the effects of high glucose on vascular endothelial dysfunction by modulating the Sirt1‐eNOS pathway. Issue 2 (15th November 2018)

• Record Type: Journal Article
• Authors: Zhai, Jinghui; Qu, Xiaoyu; Zhang, Yueming; Gao, Huan; Tao, Lina; Song, Yanqing; Zhang, Sixi
• Is Part Of: Journal of biochemical and molecular toxicology. Volume 33:Issue 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-15
• Subjects: cardiovascular disease (CVD) -- high glucose -- salvianolic acid (SA) -- Sirtuin 1 (Sirt1); Biochemistry -- Periodicals; Molecular biology -- Periodicals; Toxicology -- Periodicals; 574
• DOI: 10.1002/jbt.22245
• Languages: English
• ISSNs: 1095-6670

Abstract

Abstract: Salvianolic acid (SA) is known for improving blood circulation, scavenging hydroxyl radicals, and preventing platelet aggregation. The research explored whether SA can protect against cardiovascular disease induced by high glucose conditions. Our results indicate that SA significantly increases cells viability and nitric oxide levels while decreasing reactive oxygen species generation. SA upregulated the expression levels of Bcl‐2 and decreased the levels of Bax, cleaved caspase‐3, and cleaved caspase‐9. Furthermore, the expression levels of Sirtuin 1 (Sirt1) and p‐endothelial nitric oxide synthase (eNOS) were markedly increased in response to SA treatment. Moreover, exposure of human umbilical vein endothelial cells to Ex527 resulted in reducing expression of p‐eNOS. However, the beneficial effects of SA were abolished partially when Ex527 was added. These findings suggest that SA can be used as a potential therapeutic to protect against high glucose‐induced endothelial injury by modulating Sirt1‐eNOS pathway.