Synthesis and Biological Activity of New 4‐tert‐Butylcyclohexanone Derivatives. Issue 2 (18th January 2019)

• Record Type: Journal Article
• Authors: Kozioł, Agata; Jasnowski, Mateusz; Grela, Ewa; Szczepanik, Maryla; Gabryś, Beata; Dancewicz, Katarzyna; Lochyński, Stanisław
• Is Part Of: Chemistry & biodiversity. Volume 16:Issue 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-18
• Subjects: 4-tert-butylcyclohexanone -- lactones, bromolactones -- biological activity -- antibacterial activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201800411
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: In the synthesis performed in this study, derivatives of 4‐ tert ‐butylcyclohexanone1 were obtained using typical reactions of organic synthesis. The bioactivity of the selected compounds was evaluated. 1‐(Bromomethyl)‐8‐ tert ‐butyl‐2‐oxaspiro[4.5]decan‐3‐one (5 ) was characterized by attractant properties against larvae and a weak feeding deterrent activity against adults of Alphitobius diaperinus Panzer . This bromolactone was a moderate antifeedant towards Myzus persicae Sulzer . In addition, ethyl (4‐ tert ‐butylcyclohexylidene)acetate (2 ) and bromolactone5 displayed antibacterial activity. The strongest bacteriostatic effect was observed against Gram‐positive strains: Bacillus subtilis and Staphylococcus aureus . The bromolactone5 also limited the growth of Escherichia coli strain. Abstract :