Low incidence of acute rejection within 6 months of kidney transplantation in HIV‐infected recipients treated with raltegravir: the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE trial1. Issue 3 (27th January 2019)

• Record Type: Journal Article
• Authors: Matignon, M; Lelièvre, J‐D; Lahiani, A; Abbassi, K; Desvaux, D; Diallo, A; Peraldi, M‐N; Taburet, A‐M; Saillard, J; Delaugerre, C; Costagliola, D; Assoumou, L; Grimbert, P
• Other Names: Chesnel Chrystel investigator.; Dumont Cécile investigator.; Molina Jean‐Michel investigator.; Ponscarme Diane investigator.; Parlier Sylvie investigator.; Loze Bénédicte investigator.; Zucman David investigator.; Bornarel Dominique investigator.; Goujard Cécile investigator.; Bourdic Katia investigator.; Duvivier Claudine investigator.; Shoai‐Tehrani Michka investigator.; Touam Fatima investigator.; Boucly Ségolène investigator.; Maignan Aline investigator.; Marchou Bruno investigator.; Chauveau Marine investigator.; Balsarin Florence investigator.; Lagarrigue Sandra investigator.; Raffi François investigator.; Hüe Hervé investigator.; Brosseau Delphine investigator.; Pialoux Gilles investigator.; Slama Laurence investigator.; Adda Anne investigator.; Verdon Renaud investigator.; Bouvet Elisabeth investigator.; Louis Bernard investigator.; Nau Pascale investigator.; Didier Agnès investigator.; Aït Sahlia Nawelle investigator.; Pairière Monique investigator.; Jullien Virginie investigator.; François Véronique investigator.; Langner Nathalie investigator.; Genet Maïté investigator.; Tricot Leila investigator.; Herel Canan investigator.; Leroux Nathanael investigator.; Durrbach Antoine investigator.; Hallier Isabelle investigator.; Legaud Marie‐Thérèse investigator.; Legendre Christophe investigator.; Halley Marie‐Noëlle investigator.; Marie Bouliet investigator.; Rostaing Lionel investigator.; Kamar Nassim investigator.; Beq Audrey investigator.; Dantal Jacques investigator.; Lemauft Jean‐Xavier investigator.; Lerat Lydie investigator.; Kerandel Celine investigator.; Poulet Myriam investigator.; Rondeau Eric investigator.; Richard Martine investigator.; Ravato Sylviane investigator.; Hurault de Ligny Bruno investigator.; Ouethrani Mohamed investigator.; Randoux Christine investigator.; Vkrtovsnik François investigator.; Sedrati Nadia investigator.; Lebranchu Yvon investigator.; Pilorge Bernadette investigator.; Yadel Samia investigator.; Mohand Hassiba Ait investigator.; Ako Josiane investigator.; Rodrigues Serge investigator.; Génin Michèle investigator.; Gibowski Severine investigator.; Le Mestre Soizic investigator.; Gelley Ambre investigator.; Couffin‐Cadiergues Sandrine investigator.; Petrov‐Sanchez Ventzislava investigator.; Delfraissy Jean‐François investigator.; Dabis François investigator.;
• Is Part Of: HIV medicine. Volume 20:Issue 3(2019)
• Page Start: 202
• Page End: 213
• Publication Date: 2019-01-27
• Subjects: end‐stage kidney disease -- HIV -- HIV‐associated nephropathy -- kidney transplantation -- raltegravir; HIV infections -- Treatment -- Periodicals; HIV-positive persons -- Periodicals; HIV infections -- Treatment -- Decision making -- Periodicals; 616.9792
• DOI: 10.1111/hiv.12700
• Languages: English
• ISSNs: 1464-2662

Abstract

Abstract : Objectives: High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV‐infected recipients treated with a protease‐inhibitor‐free raltegravir‐based regimen. Methods: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single‐arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV‐1 RNA copies/mL, CD4 T‐cell count > 200 cells/μL, and HIV‐1 strains sensitive to raltegravir, aiming to demonstrate 6‐month clinical acute rejection rates < 30%. Time to transplantation was compared with that for uninfected subjects matched for age, sex and registration date. Results: In total, 61 participants were enrolled in the study, and 26 underwent kidney transplantation. Two participants experienced clinical acute rejection, corresponding to an estimated clinical acute rejection rate of 8% [95% confidence interval (CI) 2–24%] at 6 and 12 months post‐transplantation. HIV infection remained under control in all but one participant, who temporarily stopped antiretroviral treatment. Median time to transplantation was longer in PLHIV than in controls (4.3 versus 2.8 years, respectively; P = 0.002) and was not influenced by blood group. Conclusions: Acute rejection rates were low after kidney transplantation in PLHIV treated with a raltegravir‐based regimen. However, PLHIV have poorer access to transplantation than HIV‐uninfected individuals after registration on the waiting list.