Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms. Issue 1 (28th November 2018)

• Record Type: Journal Article
• Authors: Afanasyev, Oleg I.; Zarochintsev, Alexander; Petrushina, Tatiana; Cherkasova, Anastasia; Denisov, Gleb; Cherkashchenko, Ilia; Chusova, Olga; Jinho, Oh; Man‐Seog, Chun; Usanov, Dmitry L.; Semenov, Sergei E.; Chusov, Denis
• Is Part Of: European journal of organic chemistry. Issue 1(2019)
• Page Start: 32
• Page End: 35
• Publication Date: 2018-11-28
• Subjects: Aldehydes -- Nitrile -- Iron carbonyl -- CO surrogate -- Reductive alkylation -- Reduction -- Carbonyl ligands; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201801412
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed. Abstract : A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed.