Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery. (9th December 2018)

• Record Type: Journal Article
• Authors: Chen, Siyuan; Matsumoto, Hiroko; Moro‐oka, Yuki; Tanaka, Miyako; Miyahara, Yuji; Suganami, Takayoshi; Matsumoto, Akira
• Is Part Of: Advanced functional materials. Volume 29:Number 7(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-09
• Subjects: boronate hydrogel -- closed‐loop -- glucose‐responsive insulin delivery -- microneedles -- silk fibroin; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201807369
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Achieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an "enzyme‐free" polymeric microneedle (MN)‐array patch composed of a boronate‐containing hydrogel semi‐interpenetrated by biocompatible silk fibroin is developed. Consistent with the previous reports, the presence of the boronate‐hydrogel allows for glucose‐responsive diffusion‐control of insulin, while the crystalline fibroin component serves as a matrix‐stiffener to validate skin penetration. Remarkably, this "enzyme‐free" smart artificial on‐skin pancreas prototype remains stable for at least 2 months in an aqueous environment. Furthermore, it establishes sustained as well as acute glucose‐responsive insulin delivery, and is to the authors' knowledge, the first successful material design addressing such two technical challenges at once on an MN format. This long‐acting, on‐demand insulin delivery technology may offer a candidate for a next‐generation diabetes therapy that is remarkably stable, safe, economically efficient, and capable of providing both acute‐ and continuous glycemic control in a manner minimally dependent on patient compliance. Abstract : An electronics‐free, enzyme‐free, and nanoparticle‐free smart artificial on‐skin pancreas, which is a hybrid microneedle‐array patch fabricated with a glucose‐sensitive boronate‐hydrogel and biocompatible silk fibroin semi‐interpenetrating network, is developed to continuously monitor glucose levels whilst autonomously delivering insulin on demand. This microneedles‐array patch offers long‐acting persistent glycemic control in a safe, convenient, and painless way, which will significantly improve patients' life quality.