Collective Synthesis of Schilancidilactones A, B and Schilancitrilactones A, B, C, 20‐epi‐Schilancitrilactone A1. Issue 3 (6th February 2019) - Wang, Hengtao
Summary of main observation and conclusion: Schisandraceae triterpenoids are novel natural products that contain highly fused ring systems bearing multiple chiral centers surrounding. Some of them exhibit promising bioactivities, such as antitumor, anti‐HIV, etc . In this article, we describe our efforts to the collective total synthesis of schilancidilactones A, B, schilancitrilactones A, B, C, and 20‐ epi ‐schilancitrilactone A from common precursors. An intramolecular radical cyclization, late‐stage halogenation and AIBN‐mediated or Ni‐catalyzed intermolecular radical cross coupling reaction were employed as the key steps. Abstract : The collective total synthesis of schilancidilactones A, B, schilancitrilactones A, B, C, and 20‐ epi ‐schilancitrilactone A were accomplished. The key steps include intermolecular radical cyclization, late‐stage halogenation, intermolecular cross coupling of alkyl halide with vinyl stannane.