Microwave‐Assisted Synthesis of N‐Substituted Maleimide Derivatives as Exogenous Antioxidant Agents. (29th November 2018)

• Record Type: Journal Article
• Authors: Rammohan, Aluru; Mallikarjuna Reddy, Guda; Raul Garcia, Jarem; Zyryanov, Grigory V.; Sravya, Gundala; Bakthavatchala Reddy, Nemallapudi; Yuvaraja, Gutha
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 2(2019)
• Page Start: 470
• Page End: 476
• Publication Date: 2018-11-29
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3421
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A series of N ‐substituted maleimide derivatives have been developed via acetic acid‐mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H2 O2 methods. Compounds5h and5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions5h and5m generally show beneficial activity than electron capture substitution cores. Thus, compounds5h and5m may be useful as an exogenous antioxidant. Abstract :