A genome-wide association study of early gamma-band response in a schizophrenia case–control sample. (17th November 2018)

• Record Type: Journal Article
• Authors: Konte, Bettina; Leicht, Gregor; Giegling, Ina; Pogarell, Oliver; Karch, Susanne; Hartmann, Annette M.; Friedl, Marion; Hegerl, Ulrich; Rujescu, Dan; Mulert, Christoph
• Is Part Of: World journal of biological psychiatry. Volume 19:Number 8(2018)
• Page Start: 602
• Page End: 609
• Publication Date: 2018-11-17
• Subjects: EEG -- gamma -- schizophrenia -- GWAS -- Neuregulin-ErbB; Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.1080/15622975.2017.1366054
• Languages: English
• ISSNs: 1562-2975

Abstract

Abstract: Objectives: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. Methods: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). Results: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN . Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality ( P = .048). Conclusions: We identified no marker genome-wide significantly associating with gamma response; independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.