Anti-DFS70 antibodies: an update on our current understanding and their clinical usefulness. (4th March 2019)

• Record Type: Journal Article
• Authors: Mahler, Michael; Andrade, Luis E.; Casiano, Carlos A.; Malyavantham, Kishore; Fritzler, Marvin J.
• Is Part Of: Expert review of clinical immunology. Volume 15:Number 3(2019)
• Page Start: 241
• Page End: 250
• Publication Date: 2019-03-04
• Subjects: Autoantibodies -- antinuclear antibodies -- ANA -- anti-DFS70 -- dense fine speckled -- ANA associated rheumatic disease -- indirect immunofluorescence; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1080/1744666X.2019.1562903
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: Introduction : Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), there is a growing body of evidence that anti-DFS70 antibodies, when present in high titers and in isolation (without accompanying other antibodies), are useful to aid in the exclusion of ANA associated rheumatic diseases. Areas covered : This review aims to analyze and interpret the current published knowledge and recent findings to provide guidance in the use of anti-DFS70 antibodies to analyze associations of this unique autoantibody. Expert commentary : Although the association of anti-DFS70 antibodies is still unknown, their use as a biomarker that can aid in the exclusion of ANA related diseases is well-established.