Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors. (4th July 2018)

• Record Type: Journal Article
• Authors: Chin, Tong Foh; Ibrahim, Kamariah; Thirunavakarasu, Tharshanadevasheri; Azanan, Mohamad Shafiq; Oh, Lixian; Lum, Su Han; Yap, Tsiao Yi; Ariffin, Hany
• Is Part Of: Fetal and pediatric pathology. Volume 37:Number 4(2018)
• Page Start: 243
• Page End: 253
• Publication Date: 2018-07-04
• Subjects: Childhood leukemia survivors -- karyotypic abnormalities -- genomic instability; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2018.1492054
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background : Survivors of childhood cancer are at risk of developing a second malignancy. One possible mechanism for neoplastic transformation of cells is through induction of persistent genomic instability. This study aims to seek evidence of chromosomal instability in long-term childhood leukemia survivors (CLS) in one of the largest pediatric academic oncology centers in South East Asia. Methods : 50 asymptomatic (subjects have remained leukemia-free since treatment cessation) CLS and 50 healthy controls were recruited in this cross-sectional study. Of 50 CLS, 44 had acute lymphoblastic leukemia and 6 had acute myeloid leukemia. G-banded karyotyping was performed on unstimulated peripheral blood leukocytes of all subjects. Results : CLS had significantly higher occurrence of karyotypic abnormalities compared to controls. Five CLS harbored six nonclonal abnormalities (mostly aneuploidy) while none were found in controls. Conclusion : Subpopulations with nonclonal chromosomal aberrations were present in peripheral blood leukocytes of our cohort of childhood leukemia long-term survivors.