Optical coherence tomography (OCT) study in Argentinean Huntington's disease patients. (2nd December 2018)

• Record Type: Journal Article
• Authors: Gatto, Emilia; Parisi, Virginia; Persi, Gabriel; Fernandez Rey, Estela; Cesarini, Martin; Luis Etcheverry, José; Rivera, Pablo; Squitieri, Ferdinando
• Is Part Of: International journal of neuroscience. Volume 128:Number 12(2018)
• Page Start: 1157
• Page End: 1162
• Publication Date: 2018-12-02
• Subjects: Optical coherence tomography -- Huntington -- biomarkers -- neurodegenerative -- retina; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2018.1489807
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract: Background: Huntington's disease (HD) is a genetic, rare and progressive neurodegenerative disorder that causes motor and cognitive impairment in midlife patients. Although retinal damage was observed in animal HD models and in patients with other neurodegenerative diseases, we still need confirmation of impairment in HD patients. Optical coherence tomography (OCT) is a non-invasive methodology that analyses the retinal nerve fibre layers (RNFL) and could reflect processes of neurodegeneration. Methods: A cross-sectional study with 14 HD patients who underwent a spectral domain OCT. Results were compared with a control group. Demographic data were also obtained. Results: Temporal and superior RNFL sectors in HD showed a significant RNFL thinning compared with a control group. However, no differences were identified in mean total RNFL thickness between HD patients and controls. Conclusions: OCT is a rapid and non-invasive technique that can be investigated in larger cohorts of patients to assess its potential role as a biomarker in HD patients.