A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition. Issue 12 (9th January 2019)

• Record Type: Journal Article
• Authors: Dutta, Pradip Kumar; Sharma, Rupali; Kumari, Smita; Dubey, Ravindra Dhar; Sarkar, Sujit; Paulraj, Justin; Vijaykumar, Gonela; Pandey, Manoj; Sravanti, L.; Samarla, Mallik; Das, Hari Sankar; Yashpal, ; B., Heeralal; Goyal, Ravinder; Gupta, Nimish; Mandal, Swadhin K.; Sengupta, Aniruddha; Sarkar, Arindam
• Is Part Of: Chemical communications. Volume 55:Issue 12(2019)
• Page Start: 1718
• Page End: 1721
• Publication Date: 2019-01-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc06586a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new Pt(ii ) prodrug, developed by a combined drug development approach. Abstract : Diaminocyclohexane-Pt(ii )-phenalenyl complexes (1 and2 ) showed an appropriate balance between efficacy and toxicity. Compound2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.