A potential carrier for anti-tumor targeted delivery-hyaluronic acid nanoparticles. (15th March 2019)

• Record Type: Journal Article
• Authors: Cai, Jia; Fu, Jingru; Li, Ruirui; Zhang, Fang; Ling, Guixia; Zhang, Peng
• Is Part Of: Carbohydrate polymers. Volume 208(2019)
• Page Start: 356
• Page End: 364
• Publication Date: 2019-03-15
• Subjects: HA hyaluronic acid -- CD44 cluster determinant 44 -- RAHMM receptor for hyaluronic acid-mediated motility -- LYVE-1 lymphatic vessel endothelial receptor-1 -- EPR enhanced permeability and retention -- Hyal hyaluronidase -- ROS reactive oxygen species -- DOX doxorubicin -- HANP hyaluronic acid nanoparticles -- HCPT 10-hydroxycamptothecin -- CA 5β-cholianic acid -- DOCA deoxycholic acid -- Chol cholesterol -- CE ceramide -- TEM transmission electron microscope -- EDC 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide -- NHS N-hydroxysuccinimide -- DS degree of substitution -- CAC critical aggregation concentrations -- CS chitosan -- EPL ε-polylysine -- PEI polyethyleneimine -- His histidine -- PH PEI-L-histidine -- PICs polyion complexes -- FBS fetal bovine serum -- PLGA poly (D, L-lactide-co-glycolide) -- CMC critical micelle concentration -- PCL poly (caprolactone) -- PHis poly(L-histidine) -- PTX paclitaxel -- 17-AAG tanespimycin -- DTX docetaxel -- TMX tamoxifen -- NIR near-infrared -- CPT irinotecan -- CSCs cancer stem-like cells -- ICG indocyanine green -- Ce6 chlorin e6 -- PDT photodynamic therapy -- Arg-PEA arginine based poly(ester amide)s -- PTT photothermal therapy -- PEG polyethyleneglycol -- PFOB perfluorooctylbromide -- PAT photoacoustic tomography -- hBMMSC human bone marrow mesenchymal stem cell -- TPP tripolyphosphate -- CAP calcium phosphate -- siRNA Short interfering ribonucleic acid -- PEG Poly (ethylene glycol) -- GA glycyrrhetinic acid -- AMPB (3-aminomethylphenyl)boronic acid -- MTX methotrexate -- OCA octadecylamine -- CUR curcumin -- LA lipoic acid -- GSH glutathione -- HSG hyaluronic acid-glycyrrhetinic acid succinate -- Lys L-lysine methyl ester; Hierarchical targeting strategies -- Receptor-mediated endocytosis -- Synthesis of HA nanoparticles -- Modification of HA; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.12.074
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: The mechanism of the uptake and drug release of HA nanoparticles are elaborated. The synthesis of HA nanoparticles is reviewed in detail from several aspects. The latest applications of HA nanoparticles in delivery are summarized clearly. Some modification strategies are discussed for further improving the targeting and drug releasing characteristics. Abstract: In recent years, biomacromolecules have been widely used in anti-tumor delivery systems due to the biocompatibility and biodegradability. However, their applications are limited due to the lack of specific targeting. Hyaluronic acid (HA) is a natural polysaccharide and presents in extracellular matrix and synovial fluid which can specifically recognize receptors over-expressed by tumor cells. In addition, they can self-assemble into nanoparticles. HA nanoparticles provide new hierarchical targeting strategies: passively targeting tumor tissue by enhanced permeability and retention effect, actively targeting tumor cells by cluster determinant 44 (CD44) receptor, and then entering cells through receptor-mediated endocytosis. In this review, the synthesis of HA nanoparticles is described in detail from several aspects and applications are also discussed for improving the delivery of hydrophobic drugs, nucleic acids and photosensitizers into the tumor cells. In addition, the modification of HA for improving the targeting and drug releasing characteristics are also discussed.