Modelling physical resilience in ageing mice. (January 2019)

• Record Type: Journal Article
• Authors: Schosserer, Markus; Banks, Gareth; Dogan, Soner; Dungel, Peter; Fernandes, Adelaide; Marolt Presen, Darja; Matheu, Ander; Osuchowski, Marcin; Potter, Paul; Sanfeliu, Coral; Tuna, Bilge Guvenc; Varela-Nieto, Isabel; Bellantuono, Ilaria
• Is Part Of: Mechanisms of ageing and development. Volume 177(2019)
• Page Start: 91
• Page End: 102
• Publication Date: 2019-01
• Subjects: Ageing -- Physical resilience -- Mouse models -- Frailty -- Stress recovery -- Intervention testing; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2018.10.001
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: In frailty, resilience is defined as the ability to respond to adverse events. Geroprotectors are drugs which modulate mechanisms of ageing and which are able to target multiple deficits. Modelling resilience in mice can be achieved by using stressors such as traumas, sepsis, heat or cold stress, toxic agents. Loss of resilience in aged mice is the reduced ability to respond to a stressor which affects multiple tissues. Abstract: Geroprotectors, a class of drugs targeting multiple deficits occurring with age, necessitate the development of new animal models to test their efficacy. The COST Action MouseAGE is a European network whose aim is to reach consensus on the translational path required for geroprotectors, interventions targeting the biology of ageing. In our previous work we identified frailty and loss of resilience as a potential target for geroprotectors. Frailty is the result of an accumulation of deficits, which occurs with age and reduces the ability to respond to adverse events (physical resilience). Modelling frailty and physical resilience in mice is challenging for many reasons. There is no consensus on the precise definition of frailty and resilience in patients or on how best to measure it. This makes it difficult to evaluate available mouse models. In addition, the characterization of those models is poor. Here we review potential models of physical resilience, focusing on those where there is some evidence that the administration of acute stressors requires integrative responses involving multiple tissues and where aged mice showed a delayed recovery or a worse outcome then young mice in response to the stressor. These models include sepsis, trauma, drug- and radiation exposure, kidney and brain ischemia, exposure to noise, heat and cold shock.