A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy. (February 2019)

• Record Type: Journal Article
• Authors: Sun, Xiao; Zhang, Guilong; Du, Ruohong; Xu, Rui; Zhu, Dongwang; Qian, Junchao; Bai, Guo; Yang, Chi; Zhang, Zhiyuan; Zhang, Xin; Zou, Duohong; Wu, Zhengyan
• Is Part Of: Biomaterials. Volume 194(2019)
• Page Start: 151
• Page End: 160
• Publication Date: 2019-02
• Subjects: Microenvironment-responsive -- Degradable -- Combinatorial therapy -- Magnetic resonance imaging -- Nanotheranostics; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.12.004
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: In this work, a tumor microenvironment (TME)-responsive biodegradable MnSiO3 @Fe3 O4 nanoplatform for dual-mode magnetic resonance imaging (MRI)-guided combinatorial cancer therapy was constructed. Fe3 O4 nanoparticles decorated on the surface of MnSiO3 could effectively obstruct the pores of MnSiO3 and reduce the leakage of anticancer drugs under physiological conditions. The structure of the nanoplatform was broken under the weakly acidic and high-concentration glutathione conditions in the TME, resulting in the separation of the Fe3 O4 nanoparticles from the nanoplatform and rapid drug release. In addition, the exfoliated Fe3 O4 and released Mn 2+ can help reduce the interference between their T1 and T2 contrast abilities, resulting in dual-mode MRI contrast enhancement. Furthermore, during the exfoliation process of the Fe3 O4 nanocrystals, the catalytic activity of the Fe3 O4 nanocrystals toward a Fenton-like reaction within cancer cells could be improved because of the increase in specific surface area, which led to the generation of highly toxic hydroxyl radicals and induced HeLa cell apoptosis. The nanoplatform also displayed excellent T1 -T2 dual-mode MRI contrast enhancement and anticancer activity in vivo with reduced systemic toxicity. Thus, this multifunctional nanoplatform could be a potential nanotheranostic for dual-mode MRI-guided combinatorial cancer therapy. Graphical abstract: A multifunctional MnSiO3 @Fe3 O4 nanoplatform is constructed by decorating Fe3 O4 nanoparticles on the surface of MnSiO3, followed by amination and grafting PEG on the surface and subsequently loading cisplatin into the nanoplatform. This well-engineered nanoplatform with tumor microenvironment-responsive biodegradable ability displays outstanding dual-mode MRI-guided combinatorial catalytic nanotherapeutics (the generation of ·OH) and chemotherapy for cancer treatment.