Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis. (13th March 2018)

• Record Type: Journal Article
• Authors: Van Slyke, Loraine; Scott, Mia
• Is Part Of: Journal of the International Association of Providers of AIDS Care. Volume 17(2018)
• Publication Date: 2018-03-13
• Subjects: neuralgia -- tenofovir/emtricitabine -- PrEP; AIDS (Disease) -- Periodicals; 616.9792
• DOI: 10.1177/2325958218760846
• Languages: English
• ISSNs: 2325-9574

Abstract

HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the United States. While FTC/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC/TDF has not been previously described. We report the case of a 35-year-old patient who began FTC/TDF PrEP and developed acute trigeminal neuralgia. The neurologic symptoms resolved after treatment discontinuation and recurred upon rechallenge, resulting in permanent discontinuation of PrEP treatment.