Risk of myocardial infarction in patients with psoriasis: A cross-sectional patient-population study in a Japanese hospital. Issue 4 (April 2019)

• Record Type: Journal Article
• Authors: Shiba, Masayuki; Kato, Takao; Izumi, Toshiaki; Miyamoto, Shoichi; Nakane, Eisaku; Haruna, Tetsuya; Inoko, Moriaki
• Is Part Of: Journal of cardiology. Volume 73:Issue 4(2019)
• Page Start: 276
• Page End: 279
• Publication Date: 2019-04
• Subjects: Psoriasis -- Myocardial infarction -- Japan; Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2018.10.008
• Languages: English
• ISSNs: 0914-5087

Abstract

Highlights: The association between myocardial infarction (MI) and psoriasis vulgaris was almost never studied in Japan. Patients with psoriasis had a higher prevalence of metabolic comorbidities and MI. We showed the independent association between MI and psoriasis vulgaris in Japan. Abstract: Background: Some epidemiological studies have demonstrated the association between psoriasis vulgaris and coronary artery disease (CAD). However, there is a lack of specific data regarding the association between psoriasis vulgaris and myocardial infarction (MI), the more severe and critical presentation of CAD, in the Japanese population. Methods and results: We retrospectively analyzed 113, 065 patients of all ages at our hospital from January 1, 2011 to January 1, 2013. We extracted the data of patients with psoriasis vulgaris, diabetes mellitus, dyslipidemia, or MI (acute, sub-acute, or old), including sex and age from the electronic medical record database. The prevalence of MI in patients with hypertension, dyslipidemia, diabetes mellitus, and psoriasis vulgaris were 4.8% (794/16, 476), 5.0% (459/9236), 4.6% (531/11, 555), and 2.7% (32/1197), respectively. Multivariate analysis showed that psoriasis vulgaris was significantly associated with MI [adjusted odds ratio (OR): 1.87; 95% confidence interval (CI): 1.26–2.68; p = 0.0022]. In a subgroup analysis of 24, 069 patients who had one or more comorbidities including diabetes mellitus, dyslipidemia, and hypertension, psoriasis vulgaris was still independently associated with MI after adjusting for sex and age (adjusted OR, 1.49; 95% CI: 1.02–2.18; p = 0.0358) in adults. Conclusion: Psoriasis vulgaris was significantly associated with MI in a Japanese hospital-based population.