Fast continuous alcohol amination employing a hydrogen borrowing protocol. Issue 1 (19th November 2018)

• Record Type: Journal Article
• Authors: Labes, Ricardo; Mateos, Carlos; Battilocchio, Claudio; Chen, Yiding; Dingwall, Paul; Cumming, Graham R.; Rincón, Juan A.; Nieves-Remacha, Maria José; Ley, Steven V.
• Is Part Of: Green chemistry. Volume 21:Issue 1(2019)
• Page Start: 59
• Page End: 63
• Publication Date: 2018-11-19
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c8gc03328e
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A continuous flow method for the direct conversion of alcohols to amines via a hydrogen borrowing approach is reported. Abstract : A continuous flow method for the direct conversion of alcohols to amines via a hydrogen borrowing approach is reported. The method utilises a low loading (0.5%) of a commercial catalyst system ([Ru( p -cymene)Cl2 ]2 and DPEPhos), reagent grade solvent and is selective for primary alcohols. Successful methylation of amines using methanol and the direct dimethylamination of alcohols using commercial dimethylamine solution are reported. The synthesis of two pharmaceutical agents Piribedil (5 ) and Buspirone (25 ) were accomplished in good yields employing these new methods.