Comparison of the effects of 1 MHz and 3 MHz therapeutic ultrasound on endothelium-dependent vasodilation of humans: a randomised clinical trial. Issue 1 (March 2019)

• Record Type: Journal Article
• Authors: Hauck, M.; Noronha Martins, C.; Borges Moraes, M.; Aikawa, P.; da Silva Paulitsch, F.; Méa Plentz, R. Della; Teixeira da Costa, S.; Vargas da Silva, A.M.; Signori, L.U.
• Is Part Of: Physiotherapy. Volume 105:Issue 1(2019)
• Page Start: 120
• Page End: 125
• Publication Date: 2019-03
• Subjects: Endothelial function -- Vascular endothelium -- Ultrasonic therapy -- Ultrasound -- Nitric oxide; Physical therapy -- Periodicals; Therapeutics, Physiological -- Periodicals; 615.8205
• DOI: 10.1016/j.physio.2017.08.010
• Languages: English
• ISSNs: 0031-9406

Abstract

Abstract: Objective: To compare the effects of different waveforms of 1 MHz and 3 MHz therapeutic ultrasound on endothelial function in healthy subjects. Design: Randomised placebo-controlled, crossover study with concealed allocation and assessor blinding. Setting: Imaging Centre of the University Hospital. Participants: Thirty volunteers aged between 18 and 35 years were divided into two homogeneous groups (1 MHz and 3 MHz). Interventions: Continuous (CUT; 0.4 W/cm 2SATA ), pulsed (PUT; 20% duty cycle, 0.08 W/cm 2SATA ) and placebo waveforms (equipment off) of ultrasound (1 MHz and 3 MHz) were randomized and applied over the brachial artery for 5 minutes. Main outcome measures: Endothelial function was evaluated using the flow-mediated dilation (FMD) technique. Results: Both 1 MHz [CUT: mean difference 4%, 95% confidence interval (CI) 2 to 6%, P < 0.001; PUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001] and 3 MHz (CUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001; PUT: mean difference 4%, 95% CI 2 to 6%, P < 0.001) of therapeutic ultrasound increased %FMD by approximately 4% compared with the placebo waveforms. The endothelium-dependent vasodilator responses were the same for both types of waves and frequencies. No differences in baseline diameter, hyperaemic flow, and nitroglycerin-mediated diameter and vasodilation were observed between groups. Conclusion: Both CUT and PUT ultrasound waveforms improved endothelial function. The 1 MHz and 3 MHz frequencies of therapeutic ultrasound led to similar improvement in endothelial function in healthy volunteers. Clinical trial registration number RBR-4z5z3t.