Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer. Issue 5 (14th December 2018)

• Record Type: Journal Article
• Authors: Ju, Caoyun; Wen, Yajing; Zhang, Luping; Wang, Qianqian; Xue, Lingjing; Shen, Jian; Zhang, Can
• Is Part Of: Small. Volume 15:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-12-14
• Subjects: Abraxane -- cytopharmaceuticals -- gastric cancer -- human neutrophils -- radiotherapy; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201804191
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo‐radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Human NEs, the most abundant white blood cells in peripheral blood, are developed to carry Abraxane, the commercial albumin‐bound paclitaxel nanoparticle, to form cytopharmaceuticals (Abraxane/NEs) which have been confirmed to maintain the intrinsic functions of human NEs. The modest radiation is applied not only to exert tumor disruption, but also to increase the release of inflammatory factors which guide the NEs homing to the tumoral sites. These amplified inflammatory factors at tumor sites excessively activate Abraxane/NEs to form neutrophil extracellular traps, along with a burst release of Abraxane to induce superior tumor suppression. This adjuvant chemo‐radiotherapy based on cytopharmaceuticals may provide new opportunities for advanced cancer treatment, which reveals the huge clinical potential of human neutrophils as drug delivery vectors. Abstract : A cytopharmaceutical based on human neutrophils (NEs) is preapred by encapsulating commercial Abraxane into purified mature human NEs for enhanced tumor‐targeting chemotherapy, as it can respond to the amplified inflammatory signals induced by local radiotherapy due to the native inflammatory chemotaxis of NEs.