Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties. Issue 2 (2nd January 2019)

• Record Type: Journal Article
• Authors: Güzel, Emre; Koçyiğit, Ümit M.; Arslan, Barış S.; Ataş, Mehmet; Taslimi, Parham; Gökalp, Faik; Nebioğlu, Mehmet; Şişman, İlkay; Gulçin, İlhami
• Is Part Of: Archiv der Pharmazie. Volume 352:Issue 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-02
• Subjects: acetylcholinesterase -- anticholinergic -- antidiabetic -- antimicrobial -- aminopyrazole -- carbonic anhydrase -- phthalocyanine; Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201800292
• Languages: English
• ISSNs: 0365-6233

Abstract

Abstract: The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4‐(2‐(5‐amino‐4‐(4‐bromophenyl)‐3‐methyl‐1 H ‐pyrazol‐1‐yl)ethoxy)phthalonitrile (2 ) and its soluble aminopyrazole‐substituted peripheral metallo (Mn, Co, and Ni)‐phthalocyanine complexes (3 –5 ) are reported for the first time. The synthesized compounds and phthalocyanine complexes were characterized spectroscopically. The new phthalonitrile derivative (2 ) and its peripheral metallophthalocyanine complexes (3–5 ) were found to be effective inhibitors of α‐glycosidase, acetylcholinesterase (AChE), human carbonic anhydrase I and II isoforms (hCA I and II), and butyrylcholinesterase (BChE) with K i values in the range of 1.55 ± 0.47 to 10.85 ± 3.43 nM for α‐glycosidase, 8.44 ± 0.32 to 21.31 ± 7.91 nM for hCA I, 11.73 ± 2.82 to 31.03 ± 4.81 nM for hCA II, 101.62 ± 26.58 to 326.54 ± 89.67 nM for AChE, and 68.68 ± 11.15 to 109.53 ± 19.55 nM for BChE. This is the first study of peripherally substituted phthalocyanines containing an aminopyrazole group as potential carbonic anhydrase enzyme inhibitor. Also, the antimicrobial activities of the synthesized compounds were evaluated against six microorganisms (four bacteria and two Candida species) using the broth microdilution method. The gram‐positive bacteria were detected to be more sensitive than gram‐negative bacteria and yeasts in the synthesized compounds. Abstract : 4‐(2‐(5‐Amino‐4‐(4‐bromophenyl)‐3‐methyl‐1 H ‐pyrazol‐1‐yl)ethoxy)phthalonitrile2 and its soluble aminopyrazole‐substituted peripheral metallophthalocyanine complexes3–5 were synthesized and assayed for their aggregation behavior, antimicrobial, antidiabetic, and anticholinergic properties. They were found to be effective inhibitors of α‐glycosidase, acetylcholinesterase, human carbonic anhydrase I and II, and butyrylcholinesterase.