Virus‐Based Nanomotors for Cargo Delivery. Issue 2 (23rd October 2018)

• Record Type: Journal Article
• Authors: Tejeda‐Rodríguez, José A.; Núñez, Alfredo; Soto, Fernando; García‐Gradilla, Víctor; Cadena‐Nava, Rubén; Wang, Joseph; Vazquez‐Duhalt, Rafael
• Is Part Of: ChemNanoMat. Volume 5:Issue 2(2019)
• Page Start: 194
• Page End: 200
• Publication Date: 2018-10-23
• Subjects: drug delivery -- nanomotors -- virus-like nanoparticles -- virus capsides; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201800403
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: Self‐propelled nanomotors based on virus structure were designed, fabricated and characterized. Capsids from plant virus were covered on one hemisphere with platinum layer to promote motion in the presence of hydrogen peroxide. The Janus viral nanomotors (JVNs) with 25–30 nm diameter from brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) showed motion speeds of up to 9 μm/sec, depending of the peroxide fuel concentration in the medium. The JVNs can carry and deliver the chemo‐therapeutic drug Tamoxifen, and they are able to internalize into breast tumor cells without any functionalization. The therapeutic payload is released by a pH‐driven delivery action of the nanomotor. Here, the first proof of concept of a self‐propelled virus‐like nanoparticle is demonstrated. The attractive capabilities of nanomotors based on virus‐like nanoparticles (VLPs) pave the way to diverse biomedical applications. Abstract : The first self‐propelled nanomotors based on a virus structure have been designed. Virus capsids were covered on one hemisphere with a Pt layer to promote motion in the presence of H2 O2 . The nanomotor can carry and deliver the drug, and they are able to internalize into tumor cells.