Synthesis of Pd‐rGO Nanocomposite for the Evaluation of In Vitro Anticancer and Antidiabetic Activities. Issue 4 (25th January 2019)

• Record Type: Journal Article
• Authors: Hazarika, Moushumi; Boruah, Purna K.; Pal, Mintu; Das, Manash R.; Tamuly, Chandan
• Is Part Of: ChemistrySelect. Volume 4:Issue 4(2019)
• Page Start: 1244
• Page End: 1250
• Publication Date: 2019-01-25
• Subjects: Anti-diabetic -- Biomaterials -- Cytotoxicity -- Nanoparticles effect; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201802789
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Biosynthesis of Pd‐rGO nanocomposite using water extract of Zanthoxylum armatum C.DC is reported here. The nanocomposite was characterized using X‐Ray Diffraction (XRD), Fourier Transform Infrared (FT‐IR), Transmission Electron Microscope (TEM), Scanning Electron Microscope‐Energy Dispersive X‐ray Spectroscopy (SEM‐EDX), X‐ray Photoelectron Spectroscopy (XPS), Raman and Thermo‐gravimetric (TG) analysis. Similarly, the Ag‐rGO and Au‐rGO nanocomposite were synthesized using the water extract of Zanthoxylum armatum C.DC. A comparative study was done on α‐glucosidase inhibition activity and cytotoxicity effect for these nanocomposites. The α‐glucosidase inhibition assay revealed that the Pd‐rGO nanocomposite has excellent inhibitory potency compared to GO, Ag‐rGO and Au‐rGO nanocomposite respectively. In this study, the 50% inhibition concentration (IC50 ) value was observed at 0.0218 ± 0.01 and 1.051 ± 0.28 μg/ml for Pd‐rGO and GO respectively. Overall our novel findings showed that the cytotoxic effect of Pd‐rGO nanocomposite was higher than other M‐rGO (M=Ag, Au) and GO against prostate cancer DU145 cells compared to non‐tumorigenic prostate epithelial cells, RWPE‐1. Abstract : Biosynthesis of Pd‐rGO nanocomposite using natural resources and its evaluation of in vitro anticancer and antidiabetic activities is reported here. The Pd‐rGO nanocomposite has shown very significant results in evaluation of α‐glucosidase inhibition assay. Further, the cyto‐toxicity assay revealed that Pd‐rGO nanocomposite is more toxic than GO, Ag‐rGO and Au‐rGO to aggressive human prostate cancer DU145 cells compared to normal prostate epithelial RWPE‐1cells.