AgBF4-catalyzed deoxygenative C2-amination of quinoline N-oxides with isothiocyanates. Issue 2 (27th November 2018)

• Record Type: Journal Article
• Authors: Xie, Long-Yong; Peng, Sha; Jiang, Li-Lin; Peng, Xia; Xia, Wen; Yu, Xianyong; Wang, Xing-Xing; Cao, Zhong; He, Wei-Min
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 2(2019)
• Page Start: 167
• Page End: 171
• Publication Date: 2018-11-27
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo01128a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF4 -catalyzed amination of quinoline N -oxides with isothiocyanates under base-, oxidant-free and mild conditions was developed. Abstract : A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF4 -catalyzed amination of quinoline N -oxides with isothiocyanates under base-, oxidant-free and mild conditions was developed. The transformation could be performed on a gram-scale and in a sequential manner starting from quinoline N -oxide to the synthesis of benzo[4, 5]imidazo[1, 2- a ]quinoline.