Visual detection of cancer cells by using in situ grown functional Cu2−xSe/reduced graphene oxide hybrids acting as an efficient nanozyme. Issue 2 (6th December 2018)

• Record Type: Journal Article
• Authors: Guo, Qing Juan; Pan, Zi Yu; Men, Chen; Lv, Wen Yi; Zou, Hong Yan; Huang, Cheng Zhi
• Is Part Of: Analyst. Volume 144:Issue 2(2019)
• Page Start: 716
• Page End: 721
• Publication Date: 2018-12-06
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c8an01849a
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Cu2− x Se nanoparticles grown in situ on reduced graphene oxide (Cu2− x Se/rGO) acted as an efficient nanozyme. Using the Cu2− x Se/rGO as a signal transducer, a colorimetric assay for cancer cells with the naked eye has been developed. Abstract : A simple protocol for in situ growth of Cu2− x Se nanoparticles on graphene oxide hybrids (Cu2− x Se/rGO) acting as an efficient nanozyme is developed and thus a sensitive visual detection method of cancer cells is proposed. The Cu2− x Se/rGO heterogeneous nanomaterials have been proven to exhibit high peroxidase-like activity to catalyze the reaction of the peroxidase substrate in the presence of hydrogen peroxide. Herein, we used Cu2− x Se/rGO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells and a total of 63 cancer cells (MCF-7) can be distinguished by naked-eye observation. The results showed that the Cu2− x Se/rGO hybrids could be the promising nanozyme mimetics for potential applications in bioanalytical fields.