Heterogeneous Metal–Organic‐Framework‐Based Biohybrid Catalysts for Cascade Reactions in Organic Solvent. Issue 7 (2nd January 2019)

• Record Type: Journal Article
• Authors: Wang, Yangxin; Zhang, Ningning; Zhang, En; Han, Yunhu; Qi, Zhenhui; Ansorge‐Schumacher, Marion B.; Ge, Yan; Wu, Changzhu
• Is Part Of: Chemistry. Volume 25:Issue 7(2019)
• Page Start: 1716
• Page End: 1721
• Publication Date: 2019-01-02
• Subjects: cascade reactions -- enzyme immobilization -- heterogeneous catalysis -- metal–organic frameworks -- Pd nanoparticles; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201805680
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: In cooperative catalysis, the combination of chemo‐ and biocatalysts to perform one‐pot reactions is a powerful tool for the improvement of chemical synthesis. Herein, UiO‐66‐NH2 was employed to stepwise immobilize Pd nanoparticles (NPs) and Candida antarctica lipase B (CalB) for the fabrication of biohybrid catalysts for cascade reactions. Distinct from traditional materials, UiO‐66‐NH2 has a robust but tunable structure that can be utilized with a ligand exchange approach to adjust its hydrophobicity, resulting in excellent catalyst dispersity in diverse reaction media. These attractive properties contribute to the formation of MOF‐based biohybrid catalysts with high activity and selectivity in the synthesis of benzyl hexanoate from benzaldehyde and ethyl hexanoate. With this proof‐of‐concept, we reasonably expect that future tailor‐made MOFs can combine other catalysts, ranging from chemical to biological catalysts for applications in industry. Abstract : UiO‐66‐NH2 was employed to immobilize Pd nanoparticles and Candida antarctica lipase B (CalB) for the fabrication of biohybrid catalysts for cascade reactions. UiO‐66‐NH2 has a robust but tunable structure that can be utilized with a ligand‐exchange approach to adjust its hydrophobicity, resulting in catalysts with high activity and selectivity for the synthesis of benzyl hexanoate from benzaldehyde and ethyl hexanoate (see figure).