MXene‐Enabled Electrochemical Microfluidic Biosensor: Applications toward Multicomponent Continuous Monitoring in Whole Blood. (20th November 2018)

• Record Type: Journal Article
• Authors: Liu, Jiang; Jiang, Xiantao; Zhang, Ruyue; Zhang, Yang; Wu, Leiming; Lu, Wei; Li, Jianqing; Li, Yingchun; Zhang, Han
• Is Part Of: Advanced functional materials. Volume 29:Number 6(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-20
• Subjects: biomarkers -- electrochemical sensors -- in vivo detection -- microfluidic chips -- MXene; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201807326
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Continuous and real‐time sensoring has received much attention in biomarker monitoring, toxicity assessment, and therapeutic agent tracking. However, its on‐site application is seriously limited by several stubborn defects including liability to fouling, signal drifting, short service life, poor repeatability, etc. Additionally, most current methods require extra sample pretreatment, delaying timely acquisition of testing results. To address these issues, MXene‐Ti3 C2 T x based screen‐printed electrode incorporated with a dialysis microfluidic chip is constructed for a direct and continuous multicomponent analysis of whole blood. Dual‐function of MXene is developed and allows for simultaneous quantification of different target compounds through one device. Importantly, ratiometric sensing tactic is easily implemented in the system, which greatly alleviates signal drifting. As a proof of concept, this novel sensor is applied in hemodialysis, and continuous assay of urea, uric acid, and creatinine levels in human blood is realized. This work paves a new path for 2D MXene in biomedical and sensing applications. Abstract : Introduction of MXene nanosheets into microfluidic chips contributes significantly to stable and sensitive signal outputs. Particularly, MXene acts as both a carrier and electrocatalyst, providing sufficient sites for locating other agents, and rendering occurrence of electrochemical reactions. Such dual‐function, together with the elaborately designed testing chip platform and strategies, realizes simultaneous quantification of different target compounds through one device.