Coenzyme Q10 protects against burn‐induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle. Issue 2 (19th January 2019)

• Record Type: Journal Article
• Authors: Nakazawa, Harumasa; Ikeda, Kazuhiro; Shinozaki, Shohei; Yasuhara, Shingo; Yu, Yong‐Ming; Martyn, J.A. Jeevendra; Tompkins, Ronald G.; Yorozu, Tomoko; Inoue, Satoshi; Kaneki, Masao
• Is Part Of: FEBS open bio. Volume 9:Issue 2(2019)
• Page Start: 348
• Page End: 363
• Publication Date: 2019-01-19
• Subjects: burn injury -- coenzyme Q10 -- insulin resistance -- mitochondrial dysfunction -- skeletal muscle; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.12580
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Mitochondrial dysfunction is associated with metabolic alterations in various disease states, including major trauma (e.g., burn injury). Metabolic derangements, including muscle insulin resistance and hyperlactatemia, are a clinically significant complication of major trauma. Coenzyme Q10 (CoQ10) is an essential cofactor for mitochondrial electron transport, and its reduced form acts as a lipophilic antioxidant. Here, we report that burn injury induces impaired muscle insulin signaling, hyperlactatemia, mitochondrial dysfunction (as indicated by suppressed mitochondrial oxygen consumption rates), morphological alterations of the mitochondria (e. g., enlargement, and loss of cristae structure), mitochondrial oxidative stress, and disruption of mitochondrial integrity (as reflected by increased mitochondrial DNA levels in the cytosol and circulation). All of these alterations were significantly alleviated by CoQ10 treatment compared with vehicle alone. These findings indicate that CoQ10 treatment is efficacious in protecting against mitochondrial dysfunction and insulin resistance in skeletal muscle of burned mice. Our data highlight CoQ10 as a potential new strategy to prevent mitochondrial damage and metabolic dysfunction in burn patients. Abstract : Coenzyme Q10 (CoQ10) can prevent mitochondrial dysfunction, while mitigating metabolic derangements and local and systemic inflammatory responses in skeletal muscle in mice. Our data highlight the potential utility of the reduced form of CoQ10 (ubiquinol) as a novel therapeutic strategy for improving the clinical outcome of patients with severe burns.