Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in the Flexible Lifestyle Empowering Change trial. Issue 2 (21st January 2019)

• Record Type: Journal Article
• Authors: Kahkoska, Anna R.; Crandell, Jamie; Driscoll, Kimberly A.; Kichler, Jessica C.; Seid, Michael; Mayer‐Davis, Elizabeth J.; Maahs, David M.
• Is Part Of: Pediatric diabetes. Volume 20:Issue 2(2019)
• Page Start: 180
• Page End: 188
• Publication Date: 2019-01-21
• Subjects: blood glucose -- diabetes mellitus, type 1 -- glycated hemoglobin A -- hypoglycemia; Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12805
• Languages: English
• ISSNs: 1399-543X

Abstract

Abstract : Objective: To examine the prevalence and correlates of non‐severe hypoglycemia among adolescents with type 1 diabetes and suboptimal glycemic control, an understudied topic in this group. Methods: Seven days of blinded continuous glucose monitor data were analyzed in 233 adolescents at baseline of the Flexible Lifestyle Empowering Change trial (13‐16 years, type 1 diabetes duration >1 year, and hemoglobin A1c [HbA1c] 8‐13% [64‐119 mmol]). Incidence of clinical hypoglycemia (54‐69 mg/dL) and clinically serious hypoglycemia (<54 mg/dL) was defined as number of episodes ≥15 minutes. Logistic regression modeling was used to determine the correlates of long duration of hypoglycemia, categorized by median split among those who experienced hypoglycemia. Results: The sample was 76.1% non‐Hispanic white, 49.8% female, age = 14.9 ± 1.1 years, diabetes duration = 6.4 ± 3.7 years, and HbA1c = 9.6 ± 1.2% (81 ± 13 mmol/mol). Over 7 days, 79.4% of youth experienced ≥1 hypoglycemic episodes of <70 mg/dL, and 55.4% of youth experienced ≥1 hypoglycemic episodes of <54 mg/dL. Among all adolescents, the median duration of clinical hypoglycemia and clinically serious hypoglycemia was 21.9 (range 0‐250.2) and 4.3 (range 0‐209.7) minutes/day, respectively. Long duration of clinical hypoglycemia (range 1.8‐17.4% time overall) and clinically serious hypoglycemia (range 1.2‐14.6% time overall) was associated with older age and decreasing HbA1c. Long duration of clinically serious hypoglycemia also was associated with insulin pump use. Conclusions: Almost 80% of adolescents with elevated HbA1c had an episode of clinical hypoglycemia, and >50% had clinically serious hypoglycemia in a week. Increased education alongside access to emerging diabetes technologies may help to prevent hypoglycemia while improving glycemic control.