Oncological outcomes before and after the extralevator abdominoperineal excision era in rectal cancer patients treated with abdominoperineal excision in a single centre, high volume unit. (3rd January 2019)

• Record Type: Journal Article
• Authors: Lehtonen, T.; Räsänen, M.; Carpelan‐Holmström, M.; Lepistö, A.
• Is Part Of: Colorectal disease. Volume 21:Number 2(2019)
• Page Start: 183
• Page End: 190
• Publication Date: 2019-01-03
• Subjects: ELAPE -- rectal cancer; Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.14468
• Languages: English
• ISSNs: 1462-8910

Abstract

Abstract: Aim: The extralevator abdominoperineal excision (ELAPE) has been expected to reduce the risk of positive circumferential resection margins (CRMs) and local recurrence in locally advanced distal rectal cancer. The aim was to determine whether there is any difference in local recurrence rates between patients who were operated on for distal rectal cancer before and after the introduction of ELAPE in our unit. Patients and methods: In all, 206 patients with distal rectal cancer without distant metastases (T1‐4N0‐2M0) were treated with curative intent. The patients were divided into two cohorts operated in 2000–2007 (A) and 2008–2014 (B). The ELAPE procedure was introduced in 2008. Since then, it has been used in cases of T4 and T3 tumours with threatened margins. In T1–T3 tumours without threatened margins a conventional abdominal perineal excision has been performed. Results: There was no significant difference in overall survival or cancer‐specific survival between the two time periods. The local recurrence rate was 15.5% in group A and 6.7% in group B ( P = 0.048), although there was no significant difference in the cumulative local recurrence rate. Intra‐operative tumour perforation occurred significantly more often during the earlier period when ELAPE was not in use: group A 15/71 (21.1%) vs group B 11/135 (8.1%), P = 0.01. CRM was positive more often in group A (16.4%) vs group B (7.4%), P = 0.054. Conclusion: The local recurrence rate, intra‐operative tumour perforation and positive CRM rate were significantly lower during the later period when more extensive surgery (ELAPE) was performed for locally advanced T3–T4 rectal cancer with threatened margins.