Clinical value of enzyme immunoassay that detects rubella‐specific immunoglobulin M immediately after disease onset. (30th January 2019)

• Record Type: Journal Article
• Authors: Kurata, Takako; Uchino, Kiyoko; Hotta, Chiemi; Ogura, Atsushi; Miyoshi, Tatsuya; Ogawa, Tomoko; Kanbayashi, Daiki; Tanaka, Tomoyuki; Yumisashi, Takahiro; Komano, Jun
• Is Part Of: Microbiology and immunology. Volume 63:Number 1(2019)
• Page Start: 32
• Page End: 35
• Publication Date: 2019-01-30
• Subjects: immunoglobulin M -- laboratory diagnosis -- nucleic acid test -- rubella; Microbiology -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Microbiologie -- Périodiques; Immunologie -- Périodiques; 579
• DOI: 10.1111/1348-0421.12664
• Languages: English
• ISSNs: 0385-5600

Abstract

Abstract: A total of 300 patients with nucleic acid test‐confirmed rubella, mostly adults, were investigated to determine the clinical value of a rubella‐specific IgM test using an EIA kit. IgM titers increased after rash onset, the median IgM titer being significantly higher 3 days post‐onset than on previous days ( P < 0.0001). Similarly, the IgM‐positive rate at 3 days post‐onset (61.5%) was significantly higher than on previous days ( P < 0.0001). This IgM test against rubella at 3 days or more post‐disease onset provides the clinically relevant information.