BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. (2nd January 2019)

• Record Type: Journal Article
• Authors: Zhang, Yilei; Zhuang, Li; Gan, Boyi
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 1(2019)
• Publication Date: 2019-01-02
• Subjects: BAP1 -- SLC7A11 -- metabolism -- ferroptosis -- H2A ubiquitination -- tumor suppression; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1536845
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.