Author's view: epithelial plasticity metabolically reprograms normal cells towards a neoplastic-prone state. (2nd January 2019)

• Record Type: Journal Article
• Authors: Wang, Hailun; Tran, Phuoc T.
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 1(2019)
• Publication Date: 2019-01-02
• Subjects: epithelial plasticity -- hexosamine biosynthetic pathway -- O-GlcNAcylation -- epithelial-mesenchymal transition -- oncogene-induced senescence; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1543485
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: We have uncovered that epithelial plasticity programs metabolically reprogram epithelial lung cells by increasing expression of genes (e.g., glutamine-fructose-6-phosphate transaminase 2 – GFPT2 and UDP-N-acetylglucosamine pyrophosphorylase 1 – UAP1 ) critical for the hexosamine biosynthetic pathway (HBP) and elevating global protein O-GlcNAcylation – a specific type of glycosylation. We found that increased O-GlcNAcylation could suppress oncogene-induced senescence tumor suppressor pathways that ultimately led to accelerated Kras G12D -driven lung tumorigenesis.