A versatile strategy for the synthesis of sequence-defined peptoids with side-chain and backbone diversity via amino acid building blocks. Issue 5 (30th November 2018)

• Record Type: Journal Article
• Authors: Wang, Shixue; Tao, Yue; Wang, Jianqun; Tao, Youhua; Wang, Xianhong
• Is Part Of: Chemical science. Volume 10:Issue 5(2019)
• Page Start: 1531
• Page End: 1538
• Publication Date: 2018-11-30
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8sc03415j
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : De novo design and synthesis of sequence-defined peptoids via amino acid building blocks is reported. Abstract : Designing artificial macromolecules with absolute sequence order is still a long-term challenge in polymer chemistry as opposed to natural biopolymers with perfectly defined sequences like proteins and DNA. Herein, we combined amino acid building blocks and iterative Ugi reactions for the de novo design and synthesis of sequence-defined peptoids. The highly efficient strategy provided excellent yields and enables multigram-scale synthesis of perfectly defined peptoids. This new strategy furnishes the broad structural diversity of side chains, as well as backbones. Importantly, the overall hydrophobicity and lower critical solution temperature (LCST) behaviours of these precisely defined peptoids can be logically altered by variation of the sequence. By following the same Ugi chemistry, these peptoids are also conjugated to DNA in a simple way, facilitating the development of novel therapeutics.