Senescence controls prostatic neoplasia driven by Pten loss. (2nd January 2019)

• Record Type: Journal Article
• Authors: Parisotto, Maxime; Grelet, Elise; El Bizri, Rana; Metzger, Daniel
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 1(2019)
• Publication Date: 2019-01-02
• Subjects: prostate cancer -- mouse model -- senescence -- replicative stress -- DNA damage; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2018.1511205
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.