Upconversion nanocrystal 'armoured' silica fibres with superior photoluminescence for miRNA detection. Issue 49 (4th June 2018)

• Record Type: Journal Article
• Authors: Wang, Gang; Fu, Yike; Ren, Zhaohui; Huang, Jie; Best, Serena; Li, Xiang; Han, Gaorong
• Is Part Of: Chemical communications. Volume 54:Issue 49(2018)
• Page Start: 6324
• Page End: 6327
• Publication Date: 2018-06-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc03480j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A FRET biosensor, based on silica nanofibres armoured with NaYF4 :Yb, Er upcoversion nanoparticles (SiO2 @UCNP), offers a simple and quantitative methodology for cancer biomarker (miRNA-21) detection. Abstract : We have fabricated a flexible membrane, consisting of SiO2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted with molecular beacons to produce a biosensor suitable for the detection of specific microRNA and with applications in early cancer detection and point-of-care diagnosis.